AB198. Nodal regulates the differentiation of iPS cells to male germ cells via Smad2/3, Oct4 and Foxh1 activation
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چکیده
Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. Nrf2 expression. These results suggest that IDS-T2DM induces testicular cell death presumably through caspase-8 activation and mitochondria-mediated cell death pathways, and also by significantly down-regulating testicular Nrf2 expression and function. SFN up-regulates testicular Nrf2 expression, and its target antioxidant expression, which was associated with significant protection of the testis from IDS-T2DM-induced germ cell death.
منابع مشابه
AB199. Human germ cell secreting factor Nodal regulates Sertoli cell functions
Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. mechanisms of spermatogenesis. Nodal could promote proliferation of mouse spermatogonial stem/progenitor cells via Smad2/3 and oct-4 activation. The objective of this study was to determine the role of Nodal signaling in the differentiation of iPS cells to male germ ce...
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